The battle between man and malaria has continued for thousands of years. Antimalarial drugs are essential weapons to fight the disease, but their efficacy is threatened by drug resistance which continues to emerge creating a major obstacle to malaria control and jeopardizing renewed hopes for elimination. As 2016 is the first year under WHO Global Technical Strategy for Malaria 2016-2030, it filexlib. The flow diagram of the selection of P. falciparum mono-infection samples used in the present study for molecular analysis of drug resistance genes has been depicted in Fig. 2 and the baseline characteristics of the enrolled cases has been shown in Table 2. Fig. 2 Flow chart of the study sample selection Full size image Haldar and colleagues discuss markers and mechanisms of resistance to artemisinins and artemisinin-based combination therapies. They describe the identification ofPlasmodium falciparum Kelch 13 as
DOI: 10.1007/978-3-319-48683-3 Corpus ID: 201052991 Drug Resistance in Bacteria , Fungi , Malaria , and Cancer G. Arora, Andaleeb Sajid, V. Kalia Published 2017 Biology The biological membrane covers all living cells and provides an effective barrier against the passage of biologically important water-soluble solutes.
The informal consultation on the containment of malaria multi-drug resistance has been prepared and organized with the technical and administrative support of WHO Headquarters, SEARO, WPRO and WHO country offices of Cambodia and Thailand and coordinated by the Mekong Malaria Programme Office in Bangkok. The consultation was encouraged
genes associated with resistance to chloroquine and pyri-methamine was high. International-level antimalarial policy and a regional antimalarial forum are needed. I n the southwestern Indian Ocean, the epidemiologic features of malaria and antimalarial drug resistance dif-fer considerably between islands that are very close geo-graphically.
A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing
The study provides a baseline data of the status of these markers which could be very useful for the malaria control program for establishing surveillance system to monitor the emergence of malaria drug resistance for more effective treatment protocol and successful control of the disease. Limitations
Self-medication and anti-malarial drug resistance is a major challenge to malaria control in DRC and sub-Saharan Africa, and to achieve sustainable control, individual, community and governmental efforts must be aligned to stop self-medication, and strengthen the health systems against malaria. Introduction
Drug resistance in TB and malaria arises from inadequate or inappropriate use of antimicrobial agents; however, the definitions used to classify drug resistance, as well as the public health control measures, vary. These differences sometimes lead to confusion and misinterpretation by those unfamiliar with either or both diseases. Malaria sickens and kills people through several pathological mechanisms, understood to varying degrees. In addition to first- and second-line antimalarial drug treatments, adjunctive and supportive care measures (e.g., intravenous fluids, blood transfusions, supplemental oxygen, antiseizure medications) may be needed for severe manifestations.
The emergence of drug resistance to first line drugs, artemisinin combination therapies (ACTs), indicates an urgent need for in